Which is activated for nuclear fragmentation in apoptosis -
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- Caspases
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- Apaf - 1
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- Oxygen free radicals
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- None of the above
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EXP:
- Caspases and endonuclease cause chromatin fragmentation in apoptosis.
- They are inactive, so first they should be activated.
- Cytochrome ‘c’ binds with Apaf-1 and this complex activates caspases.
- Caspases cause fragmentation of chromatin and also activate endonuclease.