Which is not a 2nd generation anti–histaminic agent?

[Medicoman]

Which is not a 2nd generation anti–histaminic agent ?

• 1. Cetirizine
• 2. Cyclizine
• 3. Loratidine
• 4. Fexofenadine

exp:

Antihistaminics may be classified into first generation and second generation compounds on the basis of CNS penetration and anticholinergic properties. First Generation Anti-histaminics can penetrate blood brain barrier and possess additional anticholinergic properties which are lacking in second generation drugs. Cyclizine is a first generation whereas cetririzine, loratidine and fexofenadine are second generation drugs.