Which of the following antibiotics exhibits a long postantibiotic effect that permits once-daily dosing?
A. Gentamicin.
B. Penicillin G.
C. Vancomycin.
D. Aztreonam.
Correct answer = A.
Aminoglycosides, including gentamicin, possess a long post-antibiotic effect, especially when given as a high dose every 24 hours. Penicillin G, clindamycin, and vancomycin have a relatively short postantibiotic effect and require frequent dosing to maintain activity