Which of the following drugs acts by inhibiting the transcription of DNA to RNA?
A. Rifampicin
B. Nitrofurantoin
C. Ciprofloxacin
D. Novobiocin
Explain:- Overall inhibition of RNA synthesis by rifampicin is caused by a destabilizing effect on the binding of the intermediate oligonucleotides to the active enzyme-DNA complex. Rifampicin itself can only interact specifically with RNA polymerase if the enzyme is free or in a binary complex with DNA.