32 year old patient, presenting with multiple seizures in last month that seem to be uncontrolled by previous medications. She is recently diagnosed as bipolar disorder 3 months ago. On medication review, the physician adds a drug that has therapeutic benefit on both the conditions mentioned. Which of the following is a character of the drug added?
A- blocks T type Calcium channels
B- decreased GABA action
C- inhibition of phosphoinositol cascade
D- Dopamine antagonism
E- inhibition of histone deacytlation
Answer is E, Valproate can be very beneficial for a bipolar patient who has seizure activity. One of the characters of Valproate is that it’s an important example of Histone de-acetylase inhibitors.
Valproate increase the activity of GABA not decrease. Inhibition of phosphoinositol cascade is the one of the potential mechanisms of lithium that is not an antiseizure drug.
Valproate has no role against dopamine.
The antiseizure drug that blocks T Ca channels is Ethosuximide that has no role in bipolar disorder.