Which of the following statement about thiamine is true?
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It is a co-enzyme of lactate dehydrogenase
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Its deficiency is associated with scurvy
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Its co enzyme function is done by thiamine monophosphate
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Its co-enzyme for pyruvate dehydrogenase and α-ketoglutarate dehydrogenase
exp:
Active form (coenzyme form) of thiamine is thiamine pyrophosphate (TPP), also called thiamine diphosphate (TDP).
TPP acts as coenzyme for-
Oxidative decarboxylation:- Pyruvate dehydrogenase, a-ketoglutarate dehydrogenase, brached-chain keto acid dehydrogenase.
Transketolase in PPP
Thiamine deficiency causes beriberi. Scurvy is caused by vitamin ‘C’ deficiency.