A 12-year-old girl visits her physician for follow up after treatment with methotrexate for acute lymphoblastic leukemia. Stool analysis reveals blood in stool. Her platelet count is very low.
Which of these substances should be administered immediately?
A-Vitamin K
B-Leucovorin
C-Deferoxamine
D-Triptalin
E-Penicillamine
Answer:
This is a case of methotrexate toxicity. Leucovorin is the active form of folic acid and it reverses methotrexate toxicity except neurotoxicity.
The correct answer is B