Which one of the following is least associated with the development of gout?
Psoriasis
Lesch-Nyhan syndrome
Lymphoma
Lithium toxicity
Renal failure
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Gout: predisposing factors
Gout is a form of microcrystal synovitis caused by the deposition of monosodium urate monohydrate in the synovium. It is caused by chronic hyperuricaemia (uric acid > 0.45 mmol/l)
Decreased excretion of uric acid
drugs*: diuretics
chronic kidney disease
lead toxicity
Increased production of uric acid
myeloproliferative/lymphoproliferative disorder
cytotoxic drugs
severe psoriasis
Lesch-Nyhan syndrome
hypoxanthine-guanine phosphoribosyl transferase (HGPRTase) deficiency
x-linked recessive therefore only seen in boys
features: gout, renal failure, neurological deficits, learning difficulties, self-mutilation