α1-Antitrypsin deficiency

A 37-year-old woman with a long history of dyspnea, chronic cough, sputum production, and wheezing dies of respiratory failure following a bout of lobar pneumonia. She was a nonsmoker and did not drink alcoholic beverages. The lung at autopsy is shown in the image. Which of the following underlying conditions was most likely associated with the pathologic changes shown here?

image

  1. α1-Antitrypsin deficiency
  2. Cystic fibrosis
  3. Goodpasture syndrome
  4. Hypersensitivity pneumonitis
  5. Kartagener syndrome