A 17-year-old boy presented with breathlessness and night sweats

A 17-year-old boy presented with breathlessness and night sweats.
Investigations confirmed a diagnosis of Burkitt’s lymphoma.
What is the most likely underlying abnormality of gene expression?
A: expression of BCR-ABL
B: loss of p53
C: overexpression of BCL-2
D: overexpression of c-myc
E: overexpression of JAK2

Correct answer: D Explanation Burkitt’s lymphoma is an aggressive non-Hodgkin’s lymphoma characterised by the overexpression of c-myc, most usually due to a chromosomal translocation between chromosomes 8 and 14, bringing the c-myc gene under the control of the immunoglobulin heavy chain promoter and thus rendering it constitutively active