A 24 year old woman was prescribed azithromycin for a sexually transmitted infection. She has been using a form of contraception for the past year. Which SINGLE most likely contraceptive method is likely to be affected by azithromycin?
A. Mirena coil (IUS)
B. Intrauterine Contraceptive Device (IUCD)
C. Progestogen-only pill (POP)
D. Combined oral contraceptive pill (COCP)
E. None of the above
It was previously thought that hepatic enzyme inhibitor drugs (like azithromycin) may affect COCP but was later discovered that that there were no significant interaction Only drugs like rifampicin have an interaction with COCP. Combined hormonal contraceptives are less reliable during treatment with rifampicin. Breakthrough bleeding and spotting are common, and pregnancies have occurred when patient is on rifampicin and COCP