A 32-year-old overweight woman presents with persistent right knee pain. She denies trauma, swelling, fever, rash, or general unwellness. She has never had anything like this before. She has no significant past medical history. She leads an active but stressful life as a woman’s clothing store owner. Knees appear symmetrical with no swelling, effusion, erythema, or warmth. Distal femur is tender on palpation. Range of movement is decreased on the right. On x-ray, there is a lucent, lytic lesion over the disease femur. What is the most likely diagnosis?
- Osteoarthritis
- Osteogenic sarcoma
- Ewing’s sarcoma
- Giant cell tumor of bone
- Chondrosarcoma