A 37-year-old woman with a history of ischemic heart disease presents with disfiguring skin lesions. Physical examination shows xanthomas on the dorsal surface of both hands (shown in the figure) and xanthelasmas of the eyelids. Laboratory studies reveal serum cholesterol of 820 mg/dL and significantly elevated serum triglycerides and LDL. Which of the following histopathologic findings would be expected in a biopsy of this patient’s skin lesions?
- Dermal calcium deposits
- Foamy macrophages
- Hypertrophic scar tissue
- Multinucleated giant cells
- Smooth muscle hyperplasia