A 69-year-old woman with metastatic breast cancer

A 69-year-old woman with metastatic breast cancer develops multiple organ dysfunction and expires. The heart at autopsy weighs 380 g (normal = 230 to 280 g in women). The patient’s myocardium (right) is compared to normal myocardium (left). These pathologic findings are mostly likely due to which of the following conditions?

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  1. Amyloidosis
  2. Chemotherapy
  3. Hypertension
  4. Inflammation
  5. Ischemia