This is likely a case of Pheochromocytoma as also has family h/o RCC(which can be associated with VHL which also has Pheochromocytoma). And when there’s high risk due to familial association then we prefer doing Plasma fractionated metanephrines over urinary metanephrines but that’s not given in option so better ans is D.
•24hr VMA is when you are suspecting Neuroblastoma which occurs in age less than 2yr age + there will be painfull abdominal mass
•Other 2 options are associated with carcinoid syndrome
24 hr urine metanephrins and VMA both used for screening of pheochromocytoma .
URINE metaneph also used in screening .
VMA is measured as a screening