A researcher studying a pedigree of familial type 1 diabetes mellitus discovers a mutation in the potassium channel expressed in the cell membrane of pancreatic islet β cells. This mutation impairs closing of the potassium channel. The efficacy of which of the following agents would be most profoundly affected by this mutation?
(A) Acarbose
(B) Glargine
© Glipizide
(D) Metformin
(E) Troglitazone