Absence of Corpus callosum leads to

Absence of Corpus callosum leads to
a) Hemiparesis
b) Hemisensory loss
c) Astereognosis
d) No neurological manifestations
Correct Answer - D
No neurological manifestations [Ref: Internet reference]
Agenesis of corpus callosum is a rare birth defect (congenital
disorder) in which there is complete or partial absence of corpus
Corpus callosum is a band of tissue connecting the two hemispheres
of the brain. Fibres of corpus callosum arise from the superficial
layers of the cerebral cortex and they project to the homotypic
regions of the contralateral cortex by passing through the corpus
collosum while crossing the midline.
Clinical features of Agenesis of corpus callosum
Signs and symptoms of agenesis of corpus callosum vary greatly
among individuals.
Patients usually do not have any neurological manifestations.
However, some features common in agenesis of corpus callosum
are:- Vision impairment

  • Low muscle tone (hypotonia)
    Poor motor coordination
  • Delay in motor milestones such as sitting and walking.
    Low perception of pain
  • Delayed toilet training
  • Chewing and swallowing difficulties
  • Early speech and language delays
    Social difficulties
    Other characteristics sometimes associated with callosal disorders
    are:- Seizures
  • Spasticity
  • Early, feeding difficulties and or gastric reflux-.
  • Hearing impairments
  • Abnormal head and facial features
  • Mental retardation
    CT and MRI reveal “Bat wing” deformity of the ventricles.
    There are currently no specific medical treatments for callosal
    An important point
    The neurological abnormalities associated with corpus callosum are
    not caused by absence of corpus callosum per se.
  • These conditions are believed to be caused due to associated
    cerebral anomalies rather than in corpus callosum per sc.
  • The most common associated brain anomalies with absent corpus
    callosum are
  • Dandy walker malformation
  • lnterhenfispheric cyst with hydrocephalus
  • Migrational disorder
  • Absence of the inferior vertnis
  • The children who had the best prognosis without any significant
    neurological sequale were those with isolated agenesis of corpus
  • The children with the worst prognosis and neurological sequale
    were those with agenesis of corpus callosum and migrational
    disorder with or without Dandy — walker malformation.
  • Hence prognosis is determined primarily by the underlying or
    associated malformation.