Acanthosis nigricans is seen in?

NEET PG
#1

Acanthosis nigricans is seen in ?
a) Diabetes
b) GIT cancer
c) Hypothyroidism
d) All of the above
Correct Answer - D
Ans. is ‘d’ i.e., All of the above
Acanthosis nigricans
Acanthosis nigricans is a brown to black, velvety hyperpigmentation
of the skin. It is usually found in body folds, such as posterior &
lateral folds of neck, axilla, groin, umblicus, forehead. It typically
occurs in individuals younger than 40 years of age.
Histopathologically papillomatosis is characteristically seen;
however, there is no hypermelanosis and there is only mild
acanthosis, if present.
It is associated with

  1. Obesity (most common)
  2. Endocrinopathies —> Hypothyroidism, hyperthyroidism, insuline
    resistance diabetes, Cushing’s disease, PCOD, Bloom syndrome.
  3. Internal malignancy —> Gastric adenocarcinoma