A 16-year-old male treated for acute lymphocytic leukemia develops severe lumbar and abdominal pain. His serum amylase is markedly elevated. Which of the following agents most likely caused these findings?
Asparaginase is an enzyme that catalyzes the hydrolysis of serum asparagine to aspartic acid and ammonia. Major toxicities are related to antigenicity and pancreatitis. In addition, more than 50% of those treated present biochemical evidence of hepatic dysfunction.