All are true regarding Sunitinib except

All are true regarding Sunitinib except -
a) It inhibits tyrosine kinase receptors
b) It is used for renal cell carcinoma
c) It is used for the treatment of GIST
d) It is excreted primarily in urine
Correct Answer - D
Ans. is ‘d’ i.e., It is excreted primarily in urine
Sunitinib inhibits multiple Tyrosine kinase receptors. It inhibits
PDGF, VEGF and c-kit.
o Sunitinib and sorafinib are used in renal cell carcinoma (in RCC
there is overexpression of VEGF) and GIST (in GIST there is over
expression of C-Kit & PDGF).
o It is eliminated primarily by hepatic route with excretion in faeces.