An obese 32 yr old man presents wd increasing difficulty catching his breath

An obese 32 yr old man presents wd increasing difficulty catching his breath. History of wheezing n productive cough +ve.He was told that his lungs are lacking a particular enzyme due to genetic mutation.history of smoking for past 15 yrs.Family history is significant for a father with significant lung disease. X RAY of chest shows basilar hyperlucency that is localized solely to the lung bases not apices. The pt is also at increased risk for which other condition??

A cor pulmonale
B liver cirrhosis
C pseudomonal pneumonia
D renal cyst