Anemia of Inflammation

Anemia of Inflammation

Anemia of inflammation (also referred to as anemia of chronic disease) has been recognized for more than 60 years as a mild to moderately severe anemia (hemoglobin level, 7 to 12 g per deciliter) that develops in the context of systemic inflammation because of decreased production of erythrocytes, accompanied by a modest reduction in erythrocyte survival.1 The disorder, like iron-deficiency anemia, is characterized by low serum iron levels (hypoferremia), but it differs from iron-deficiency anemia in that iron stores are preserved in marrow macrophages, as well as in splenic and hepatic macrophages that recycle senescent erythrocytes. Thus, anemia of inflammation is primarily a disorder of iron distribution.