Antimetabolites used in cancer chemotherapy
Compounds with structural similarity to precursors of purines or pyrimidines ( syntheric nucleotides ), or compounds that interfere with purine or pyrimidine synthesis are called antimetabolites.
Methotrexate: inhibits dihyrofolate reductase competitively
Hydroxyurea: inhibits ribonucleotide reductase
6- mercaptopurine: purine analog
6 -thioguanine: Nucleotide analog
6 -Azaguanine: Nucleotide analog