As clearance decide maintenance dose and Not loading dose

NEET PG
#1

  1. As clearance decide maintenance dose and Not loading dose. Then is this statement correct that Dose adjustment for Digoxin in Renal Impairment is required in Maintenance dose AND NOT in Loading dose?

  2. Sir does MI Increases Digoxin Distribution to heart and muscles?

  1. Yes

  2. No, MI increases sensitivity of digoxin to these muscles.

thank you…