Autosomal recessive Polycystic kidneys - all are true except -

Autosomal recessive Polycystic
kidneys - all are true except -
a) Seen in adults
b) Defective gene is PKHD1
c) Both kidneys show innumerable cysts
d) USG shows salt and pepper appearance
Correct Answer - A
Amswer- A. Seen in adults
Childhood polycystic kidney disease has autosomal recessive
inheritance, therefore it is also known as autosomal recessive
polycystic kidney disease.
Defective gene is the PKHD1 (Polycystic Kidney and Hepatic
Disease1) which codes for a protein fibrocystin
Both kidneys are markedly enlarged and show innumerable cysts
radiating from medulla the cortex.
MRI of kidney shows radially arranged fusiform dilated collecting
ducts.
Prenatal USG shows a salt and pepper appearance of kidney