Basal Cell Carcinoma Clinical

Basal Cell Carcinoma
Clinical
:diamonds: Well-delineated, pearly, translucent, pink-tan papules or nodules with telangiectasia
:diamonds: Superficial, nodular/ulcerative, pigmented, diffuse,
morpheaform and fibroepitheliomatous variants exist
:diamonds: Most are found on sun-exposed skin of the elderly, but
occasional cases are evident on non-sun-exposed skin
:diamonds: Basal cell carcinoma is currently the most common
cutaneous malignancy, and the incidence is increasing
:diamonds: Risk of developing basal cell carcinomas is related to
sun-exposure and skin type
:diamonds: Multiple tumors are seen in Basex syndrome and basal
cell carcinoma- nevus syndrome (Gorlin’s syndrome),
an autosomal dominant inherited disease also having
odontogenic keratocysts, palmar-plantar pits, ectopic
calcification and skeletal abnormalities
:diamonds: Basal cell carcinoma has little tendency to metastasize
Microscopic
:diamonds: A proliferation of atypical basaloid cells in nests,
trabeculae and/or cysts within the dermis but often
demonstrating multifocal epidermal attachment
:diamonds: Peripheral palisading, stromal retraction, mucin deposi-
tion, single cell necrosis and mitoses are characteristic
and are useful in separating this tumor from other
entities
:diamonds: Nodulocystic, metatypical (keratotic), pigmented,
adenoidal, infiltrating, superficial and morpheaform
histologic variants exist with the latter two having an
increased risk of recurrence