Can the eye help achieve islet transplant tolerance in type 1 diabetes?
Scientists show in experimental and preclinical recipients that islets transplanted in the eye can survive and function long-term without continuous immunosuppression, and, moreover, that initial islet transplants within the eye may lead to long-term peripheral immune tolerance to islets in other transplant sites.
Midhat H. Abdulreda, Dora M. Berman, Alexander Shishido, Christopher Martin, Maged Hossameldin, Ashley Tschiggfrie, Luis F. Hernandez, Ana Hernandez, Camillo Ricordi, Jean-Marie Parel, Ewa Jankowska-Gan, William J. Burlingham, Esdras A. Arrieta-Quintero, Victor L. Perez, Norma S. Kenyon, Per-Olof Berggren. Operational immune tolerance towards transplanted allogeneic pancreatic islets in mice and a non-human primate. Diabetologia, 2019; DOI: 10.1007/s00125-019-4814-4
