Cardiac amyloidosis Causes thickening of ventricular wall Or not?

Cardiac amyloidosis

Causes thickening of ventricular wall

Or not ?

Uworld in one ques says there is thickening

In other ques says only stiffening

There is both thickness and stiffness. I guess what they are trying to say is … the REASON behind impaired diastolic filling is stiffness rather than thickness. I’m not sure

but in first one it says stiffening rather than thickening

a pathological thickening leads to non compliance due to stiffening. Whereas in physiological thickening eg. In athelets its not stiff… In other words… You are correct.

In this type of restrictive cardiomyopathy amyloid proteins(AL/TTR) deposits in the extracellular matrix of both ventricles and atria.so myo

Myocardial wall thickness increases.the proteins kill myocytes via microvascular invasion and ischemia and/or reactive oxygen species…so eventually there are lesser and lesser myocytes…and ventricular wall grows stiffer and less compliant.