Chronic treatment with omeprazole causes following ADRs except
A. Spontaneous bacterial peritonitis in patients with ascites
B. Increased risk of bone fracture
C. Vitamin B 12 Deficiency
Spontaneous bacterial peritonitis in patients with ascites
Spontaneous bacterial peritonitis (SBP) is a known adverse drug reaction (ADR) associated with chronic treatment with omeprazole in patients with ascites. Omeprazole and other proton pump inhibitors (PPIs) can increase the risk of SBP in individuals with ascites, a condition characterized by an accumulation of fluid in the peritoneal cavity. The reduction in gastric acid secretion caused by omeprazole may allow for the overgrowth of bacteria in the gut, potentially leading to SBP in susceptible individuals. Therefore, option A is accurate.