Ccumulations of triglyceride fat droplets within hepatocytes is known as Fatty liver or Steatosis

STEATOSIS


• Accumulations of triglyceride fat droplets within hepatocytes is known as Fatty liver or Steatosis.
• Two types
A) MICROVESICULAR
( multiple tiny droplets not displacing nucleus)

1)Reye syndrome
2)Acute Fatty liver of pregnancy
3)Jamaican vomiting sickness
4) Drugs—valproic acid ; tetracycline
5) Wolman disease
6) Lysosomal acid lipase deficiency
7) Early alcoholic liver disease
8 ) chronic viral hepatitis

B ) MACROVESICULAR
(single large droplet displacing nucleus to periphery)

  1. Late alcoholic liver disease
  2. Diabetes Mellitus – insulin resistance
  3. lipodystrophy
    4)Protein energy malnutrition ;starvation
  4. dysbetalipoproteinemia
  5. TPN; Jejunoileal bypass
  6. Inflammatory bowel disease
    8 )Syndrome X (obesity; DM; hypertriglyceridemia)
    9)Drugs—estrogens ; calcium Channel Blockers