CD59 marker of which disease-

CD59 marker of which disease
a) PNH
c) BRR
d) Cowden syndrome
Correct Answer - A
Answer: A. Paroxysmal nocturnal hemoglobinuria (PNH)
Paroxysmal nocturnal hemoglobinuria (PNH) is a disease, due to
acquired mutations in “Phosphatidylinositol
GlycanComplementation Group A” gene (PIGA)…
Associated with deficiency of glycosylphosphatidylinositol
(GPI) anchor proteins along with absence of external surface
membrane proteins attaching to it.
CD55 (DAF) and CD59 (MIRL) are two such complement defence
CD59 deficiency:
Common finding in RBCs & WBCs of patients with chronic
hemolysis suffering from PNH
The definite diagnosis based on demonstration of a substantial
proportion of patient’s RBC having increased susceptibility to
complement (C), due to the deficiency on their surface of proteins
(particularly CD59 & CD55)