Contrary to past teaching, no definite causal link between inherited thrombophilias and adverse pregnancy outcomes exists. The confusion was caused by a number of observational studies that were later followed by large prospective cohort studies.
Currently, the American College of Obstetricians and Gynaecologists (2020a) does not recommend inherited thrombophilia screening for women with a history of fetal loss or adverse pregnancy outcomes such as fetal-growth restriction, placental abruption, and preeclampsia.
There are no convincing data that link inherited thrombophilias and fetal loss.
Stillbirths also are not more common with heterozygous mutations, but there is a weak association with homozygous factor V Leiden mutation. Lastly, there is insufficient evidence to screen for inherited thrombophilias in women with a fetal death.