Diabetes: Why do beta cells refuse to release insulin?

Diabetes: Why do beta cells refuse to release insulin?

  • Diabetes is worldwide one of the most widespread diseases.

  • In the most common form of diabetes, type 2 diabetes, the body cells react increasingly insensitively to the hormone insulin, which is produced by beta cells in the pancreas and is intended to promote the absorption of sugar from the blood into the cells.

  • What causes the lack of insulin production in people with type 2 diabetes?

  • Scientists have discovered that the B-cells are instructed by “leader cells” to produce insulin.

  • When these “leader cells” are destroyed the ability to produce insulin by B-cells is terminated.

Victoria Salem, Luis Delgadillo Silva, Kinga Suba, Eleni Georgiadou, S. Neda Mousavy Gharavy, Nadeem Akhtar, Aldara Martin-Alonso, David C. A. Gaboriau, Stephen M. Rothery, Theodoros Stylianides, Gaelle Carrat, Timothy J. Pullen, Sumeet Pal Singh, David J. Hodson, Isabelle Leclerc, A. M. James Shapiro, Piero Marchetti, Linford J. B. Briant, Walter Distaso, Nikolay Ninov, Guy A. Rutter. Leader β-cells coordinate Ca2 dynamics across pancreatic islets in vivo. Nature Metabolism, 2019; 1 (6): 615 DOI: 10.1038/s42255-019-0075-2