The key difference between caseating and noncaseating granulomas is that caseating granuloma has a whitish, cheese like debris at the center whereas noncaseating granuloma has no such center that has undergone necrosis.
Granulomas form in response to an infection or an inflammatory state. Crohn’s disease (CD) is a chronic transmural inflammatory bowel disease of unknown etiology. Granuloma is considered the hallmark of microscopic diagnosis in CD, but granulomas can be detected in only 40-60% of surgically resected bowel segments in CD patients. Thank you.