Dihydroergotamine differs from ergotamine in following respect :
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- It is a more potent oxytocic
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- It has antiemetic property
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- It has high oral bioavailability
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- It is more potent a adrenergic blocker and less potent vasoconstrictor
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EXP:
Hydrogenation of ergot alkaloids decrease their vasoconstrictor action and increase the α-blocking activity.