Down’s syndrome is most commonly caused by:

NEET PG Pathology
#1

  1. Characteristic pathological finding in
    carcinoid heart disease is:
    A. Fibrous endocardial thickening of right
    ventricle, tricuspid valve & pulmonary
    valve
    B. Endometrial thickening of tricuspid
    valve with severe tricuspid stenosis
    C. Collagen rich, elastic deposits in
    endocardium of right ventricle and
    pulmonary valve
    D. Calcification of tricuspid and
    pulmonary valve
    Ans: A.

  2. A female presents with history of
    progressive breathlessness. Histology
    shows heterogenous patchy fibrosis with
    several fibroblastic foci. The most likely
    diagnosis is:
    A. Cryptogenic organizing pneumonia
    B. Non specific interstitial pneumonia
    C. Usual interstitial pneumonia
    D. Desquamative interstitial pneumonia
    Ans: C.

  3. Chromophobe variant of renal cell
    carcinoma is associated with
    A. VHL gene mutations
    B. Trisomy of 7 and 17 (+7, +17)
    C. 3 p deletions (3p-)
    D. Monosomy of 1 and Y (-1, -Y)
    Ans: D.

  4. All of the following condition are
    associated with granulomatous pathology,
    except:
    A. Wegner’s granulomatosis (WG)
    B. Takayasu Arteritis (TA)
    C. Polyarteritis Nodosa (Classic PAN)
    D. Giant cell arteritis (GCA)
    Ans: C.

  5. Electron microscopy is diagnostic in:
    A. Goodpasture’s syndrome
    B. Alport’s syndrome
    C. Wegener’s syndrome
    D. Chung strauss syndrome
    Ans: B.

  6. Which of the following is the most
    characteristic ultrastructural feature of
    paraganglioma on electron microscopy?
    A. Shrunken mitochondria
    B. Large Golgi apparatus
    C. Frequent mitoses
    D. Dense core neuroendocrine granules
    Ans: D.

  7. Which of the following is a marker of
    langerhans cell histiocytosis?
    A. CD 1a
    B. CD 10
    C. CD 30
    D. CD56
    Ans: A.

  8. Hypercoagulation in nephritic
    syndrome is caused by
    A. Loss of Antithrombin III
    B. Decreased fibrinogen
    C. Decreased metabolism of vitamin K
    D. Increase in protein C
    Ans: A.

  9. Which of the following markers is
    specific for Gastro intestinal stromal
    tumors (GIST)?
    A. CD 117
    B. CD 34
    C. CD 23
    D. S – 1000
    Ans: A.

  10. Down’s syndrome is most commonly
    caused by:
    A. Maternal nondisjunction
    B. Paternal Nondisjunction
    C. Translocation
    D. Mosaicism
    Ans: A.