Drugs used in ALL in child are all
except -
a) Methotrexate
b) Vincristine
c) Vinblastine
d) Cyclophosphamids
Correct Answer - C
Answer- C. Vinblastine
Treatment of ALL is divided into 4 stages. The total duration of
treatment ranges between 2 and 2% years.
- Induction of remission
Induction therapy is used to attain remision, i.e., to eradicate the
leukemic cells from bone marrow.
Drugs used are 4 Vincristine, Prednisolone, L - Asparginase,
Anthracycline. Duration of therapy is 4-6 weeks… - CNS therapy
Most children with leukemia have subclinical CNS involvement at the
time of diagnosis. Moreover, CNS acts as a sanctuary site where
leukemic cells are protected from systemic chemotherapy because
of blood brain barrier. So, treatment to keep leukemia cells from
spreading to the CNS is often started with induction.
Treatment include 4 Intrathecal methotrexate plus cranial radiation. - Intensification
If the patient goes into remission, the next step is to intensify the
therapy for a short period.
Drugs used are 4 Methotrexate, L - Asparginase,
Epipodophyllotoxin, Cyclophosphamide, Cytarabine. - Maintenance therapy
After consolidation, the patient is generally put on a maintenance
therapy to maintaine the remission state and prevent relapse.
Drugs used are 4 6-mercaptopurine, Methotrexate, Prednisolone,
Vincristine. Duration of maintenace therapy is 2-2.5 years.