DUCHENNE MUSCULAR DYSTROPHY(DMD
Q-1 Most common hereditary neuromuscular disorder is?
A- Spinal Muscular Atrophy (SMA)
B- Duchenne Muscular Dystrophy (DMD)
C- Myotonic Dystrophy
D- Limb-Girdle Muscular Dystrophy(LGMD)
Q-2 Dystrophin Gene located at which chromosome?
A- Long arm of X chromosome at 21.2 position(Xq21.2)
B- Long arm of X chromosome at 11.2 position(Xq11.2)
C- Short arm of X chromosome at 21.2 position(Xp21.2)
D- Short arm of X chromosome at 11.2 position(Xp11.2)
Q-3 characteristic clinical features of DMD are all EXCEPT ?
A- Progressive weakness
B- Hypertrophy of the calf muscle
C- Intellectual impairment
D- Progressive fibrosis in muscle
Q-4 " Gowers sign" is seen for ?
A- Neuromuscular Disorders
B- Distal Muscle weakness
C- Proximal Muscle weakness
D- Muscular atrophies
Q-5 Commonest complication of DMD is?
A- Ventricular arrhythmia
B- Conduction Defect
C- Pericardial Effusion
D- Dilated Cardiomyopathy
Q-6 Gold standard test for DMD is?
A- Markedly Raised Serum Creatinine Kinase level
B- Muscle Biopsy
C- Mutation of dystrophin gene
D- Muscular MRI
Q-7 Dose of prednisolone to be given in DMD is/are?
A- 0.75 mg/kg/day -daily
B- 10 mg/kg/week on weekends
C- 10 day on/10 day off regimen @ 0.75mg/kg/day
D- Any of the above
Q-8 Cause of death in DMD are all EXCEPT?
A- Pneumonia
B- Heart Failure
C- Meningitis
D- Respiratory Failure