Dysplastic nevus syndrome

Dysplastic nevus syndrome:
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● An autosomal dominant disorder with numerous dysplastic nevi.

■ They are ssociated with mutations in proteins associated with cell cycling (e.g., cyclin-dependent kinase 4 ,CDK4); acquired NRAS and BRAF mutations are also common.

■ Half of such patients will develop melanomas by age 60 years.