The enzyme deficient in Wolman disease is?
A. Alpha galactosidase A
B. Aryl sulphatase A
D. Acid lipase
Correct answer: D. Acid lipase
Wolman disease is a lysosomal storage disease caused by deficiency of acid lipase.
The major accumulating metabolites are cholesterol esters and triglycerides.
Diseases caused by deficiency of other enzymes:
Alpha galactosidase A – Fabry disease
Aryl sulphatase A – Metachromatic leukodystrophy
Galactosylceramidase – Krabbe disease