Enzyme deficient in wolman disease

The enzyme deficient in Wolman disease is?
A. Alpha galactosidase A
B. Aryl sulphatase A
C. Galactosylceramidase
D. Acid lipase

Correct answer: D. Acid lipase


Wolman disease is a lysosomal storage disease caused by deficiency of acid lipase.
The major accumulating metabolites are cholesterol esters and triglycerides.
Diseases caused by deficiency of other enzymes:

Alpha galactosidase A – Fabry disease
Aryl sulphatase A – Metachromatic leukodystrophy
Galactosylceramidase – Krabbe disease