Febrile response in CNS is mediated by-

Febrile response in CNS is mediated by-

    1. Bacterial toxin
    1. IL-1
    1. lL-6
    1. Interferon
    1. All of the above

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Exp:

Pyrogenes

  • Pyrogenes are substances that cause fever.

  • Pyrogens may be exogenous or endogenous

  • Exogenous → Bacterial toxins

  • Endogenous → IL-1, TNF- α, IL-6, Interferons, Ciliory’s neurotropic factor

  • These pyrogenes increase the level of PGE 2 in the hypothalamus that elevates the thermoregulatory set point and causes fever.