Fighting the cold virus and other threats, body makes trade-off, says study

Fighting the cold virus and other threats, body makes trade-off, says study

  • Rhinovirus is a leading cause of the common cold, asthma attacks, and other respiratory illnesses.

  • When the cold virus enters the nose, cells that line the airways, known as epithelial cells, respond and often clear the virus before it can replicate and trigger symptoms.

  • Researchers have revealed how cells in different parts of the human airway vary in their response to the common cold virus.

  • These findings could help solve the mystery of why some people exposed to the cold virus get ill while others don’t.

Valia T. Mihaylova, Yong Kong, Olga Fedorova, Lokesh Sharma, Charles S. Dela Cruz, Anna Marie Pyle, Akiko Iwasaki, Ellen F. Foxman. Regional Differences in Airway Epithelial Cells Reveal Tradeoff between Defense against Oxidative Stress and Defense against Rhinovirus. Cell Reports, September 11, 2018 DOI: 10.1016/j.celrep.2018.08.033