For the management of tumor lysis syndrome, is forced alkaline diuresis done?
DOC - Allopurinol
Alkaline diuresis is not done but aggressive hydration is done. Bcoz increase in ph although increases solubility of uric acid but decreases solubility of xanthine and hypoxanthine causing intratubular crystallization. Therefore alkaline diuresis not done
Allopurinol and Rasburicase are mainstay of management.