Griseofulvin primarily targets dermatophytes

Griseofulvin primarily targets dermatophytes by binding to tubulin, thereby disrupting microtubule function and inhibiting mitosis in these fungi.This mechanism is highly effective against dermatophytes such as Trichophyton and Microsporum species, which are the primary targets of griseofulvin therapy.

Candida and Malassezia species, however, exhibit intrinsic resistance to griseofulvin. Candida species, which are yeasts, and Malassezia species, which are lipid-dependent yeasts, do not rely on the same microtubule dynamics as dermatophytes for their growth and replication. Consequently, the disruption of microtubules by griseofulvin does not significantly affect these organisms.

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