how can clozapine cause sialorrhea as well as dry mouth as side effect at the same time ?
Clozapine increases salivation through its muscarinic M4 receptor activation or blockade of alpha2-adrenoceptors, or by causing a distortion in swallowing reflex.
doesn’t it cause M receptor blockage??
Sialorrhea is primarily thought to be due to inability to swallow saliva plus Clozapines M4 or partial agonism also plays a role in increased secretion.
but isn’t there M-Receptor block ?