How does chronic renal failure cause pancreatitis?by hypercalcemia?
Hi Rohit Sharma, In most patients with CKD, chronic renal failure is idiopathic. Patients with CKD on dialysis can develop pancreatits due to toxic substances in peritoneal dialysis (PD) dialysate, bags, and tubing; alterations in serum calcium and parathyroid hormone; and bacterial and viral infections are some contributing factors. Calcium in the PD solution can also lead to pancreatitis. Increase in various gastrointestinal hormones such as cholecystokinin, gastric inhibitory polypeptide, and glucagon in patients with CKD can stimulate hypersecretion of pancreatic enzymes such as trypsin which can contribute to impairment in pancreatic function. Thank you.