In Alzheimer, what is role of Apo E-4, it increases or dec risk?

In Alzheimer, what is role of Apo E-4, it increases or dec risk?

Apo E4increases the risk and Apo E2 decreases the risk

Increases Chris Hemsworth is biallelic for this,took a break from acting

apo E2 decreses risk of alzheimer as it is protective for it