in anencephalic male foetus why abnormal development of internal and external genital organs ?
Ma’am my doubt is that development should be normal na since in intrauterine life the hormone responsible for leydig cell stimulation is HCG
After birth there should be a problem due to pituitary hypoplasia .
In anencephalic male fetuses, the abnormal development of internal and external genital organs is not directly related to the absence of the brain structures. Anencephaly is a severe neural tube defect where the brain and skull do not develop properly.
The development of internal and external genital organs in males is primarily regulated by hormones, particularly testosterone, which is produced by the testes. Testosterone production is controlled by the hypothalamic-pituitary-gonadal axis, involving the hypothalamus, pituitary gland, and the testes.
In the case of anencephaly, the absence of brain structures does not significantly impact the development of the testes or their ability to produce testosterone during intrauterine life. Therefore, during fetal development, the production of testosterone and the stimulation of Leydig cells by human chorionic gonadotropin (hCG) should proceed relatively normally.
However, it is important to note that anencephaly is often associated with other congenital abnormalities or malformations, and some of these conditions can affect the development of the reproductive organs. The specific abnormalities in the development of internal and external genital organs in anencephalic fetuses are likely due to other factors or genetic abnormalities unrelated to the absence of brain structures.
After birth, the lack of proper brain development in anencephalic individuals can lead to a range of issues, including problems with pituitary function. Pituitary hypoplasia or dysfunction can affect the production and regulation of hormones, including those involved in reproductive development and function. However, the abnormal development of internal and external genital organs in anencephaly primarily occurs during the fetal stage and is not solely due to pituitary hypoplasia after birth.