In CLL there is increased level of igG but robins states that hypogammaglobulinemia is common.Kindly clear this doubt
The other end of the spectrum are asymptomatic patients with monoclonal B cells in theier peripheral blood but is numbers that are too few to merit the diagnosis of CLL these abnormal B cells oftern have some of the same genetic trisomy 12,yet only abouyt 1% of such patients progress to symptomatic CLL per year presumably due to aquisition of additional genetic lesions