In CLL there is increased level of igG but robins states that hypogammaglobulinemia is common

In CLL there is increased level of igG but robins states that hypogammaglobulinemia is common.Kindly clear this doubt

The other end of the spectrum are asymptomatic patients with monoclonal B cells in theier peripheral blood but is numbers that are too few to merit the diagnosis of CLL these abnormal B cells oftern have some of the same genetic trisomy 12,yet only abouyt 1% of such patients progress to symptomatic CLL per year presumably due to aquisition of additional genetic lesions