in cyanide poisoing(histoxic hypoxia) even though arterio venous oxygen difference is less then how could be the peripheral chemoreceptors are maximally stimulated sir.
In cyanide poisoning ,cells cannot use oxygen to produce ATP by oxidative phosphorylation as cyanide is toxic to complex 4 of ETC…so the cells will go for anaerobic glycolysis which will produce lactic acid…so there will lactic acidosis,and the H + ion will stimulate the peripheral chemoreceptors
Cyanide causes histotoxic hypoxia, and thus, by preventing the O2 utilization at the tissue level; it acts as the powerful stimulus for peripheral chemoreceptors. Even though Po2 level of blood is normal in case of cyanide poisoning the sensors in carotid and aortic bodies are not able to sense oxygen in blood because of blockade of cellular respiration and hence, they go in for hypoxic state and gets stimulated. Thank you.